OUR PRODUCTS
Each rectal suppository contains 10 mg or 20 mg piroxicam
- Preoperative preparation of the coronary artery
- The third trimester of pregnancy, due to the risk of premature closure of the ductus arteriosus and prolonged delivery
- For breastfeeding women, because of the potential for serious adverse reactions in infants
- Severe uncontrolled heart failure
- Known hypersensitivity to piroxicam or to any of the components / excipients of piroxicam.
- A history of asthma or allergic reactions after taking acetylsalicylic acid ASA or other NSAIDs (ie complete or partial syndrome of ASA intolerance sinusitis, urticaria/angioedema, adenoids, asthma).
- Active gastric/duodenal/peptic ulcer or active inflammatory disease of the gastrointestinal tract system, active GI bleeding, or patients with a recent or recurrent history of these conditions.
- Piroxicam suppositories should not be used in patients with any inflammatory lesions of the rectum or anus, or in patients with a recent history of rectal or anal bleeding.
- Cerebral vascular hemorrhage or other bleeding disorders
- Inflammatory bowel disease
- severe liver impairment or active liver disease
- Severe renal impairment (creatinine clearance <30 mL/min or 0.5 mL/sec)
- Medicines with a high protein content: Piroxicam is highly protein bound and therefore may be expected to replace other protein bound drugs.
- Acetylsalicylic acid (ASA) or other NSAIDs: Not recommended due to the lack of any evidence demonstrating synergistic benefits and potential for additive side reactions.The exception is the use of low-dose ASA to protect the heart and blood vessels,
- Anticoagulants: Concomitant use of NSAIDs and anticoagulants increases the risk of gastrointestinal adverse events such as ulceration and bleeding and therefore monitoring is necessary in this case.
- Anti-hypertensives: NSAIDs may reduce the hypotensive effect of Angiotensin converting enzyme (ACE) inhibitors
- Cholestyramine: simultaneous use reduces the effect of piroxicam (ie reducing the half-life by 40% and increasing clearance by 52%). Therefore, the periods must be spaced when taking the necessary dose.
- Cyclosporine: Inhibition of renal prostaglandin activity by NSAIDs may increase the plasma concentration of cyclosporine and/or the risk of cyclosporine-induced nephrotoxicity.
- Diuretics: NSAIDs can reduce the effect of diuretics.
- Glucocorticoids: concomitant use of NSAIDs and glucocorticoids increases
- Risk of gastrointestinal adverse events such as ulceration and bleeding.
- Lithium: The plasma concentration of lithium increases with simultaneous use.
- It is used to relieve symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis (a condition associated with arthritis in the spine and between the spine and pelvis).
- Piroxicam relieves pain and reduces swelling and inflammation by reducing a substance in the body that causes inflammation and pain. Piroxicam does not treat the condition or prevent it from getting worse.
Dosage:
- Zorsicam should be used only at the lowest effective dose for the shortest possible period of time
- The recommended starting dose is a single daily dose of 20 mg or 10 mg twice daily.
- In rheumatoid arthritis and ankylosing spondylitis, most patients are maintained at 20 mg per day. Some patients may be maintained at a dose of 10 mg per day.
- In osteoporosis, the usual maintenance dose is 10-20 mg daily.
- Hepatic Insufficiency: A significant portion of the excretion of piroxicam by the liver occurs in metabolic processes. Thus, patients with liver disease may require reduced doses of Zorsicam and it should not be used in cases of severe liver impairment or active liver disease.
- Renal impairment: The dose should be adjusted in patients with impaired renal function, and its use is contraindicated in severe renal impairment and in cases of worsening renal disease.
Nausea, vomiting, constipation, loss of appetite, peptic ulcer, pancreatitis, hypoglycemia, low hematocrit, eosinophilia, rash, bruising, headache, dizziness, insomnia and anxiety, edema, dysuria, interstitial nephritis, hyperkalemia, Nephrotic syndrome and other uncommon side effects